Sub-Saharan Africa • ICEMR

International Center of Excellence for Malaria Research

Good morning, Malaria

and in case I don't see ya, good afternoon, good evening, and good night!

Adaptive Interventions
and Smart Trial

Optimizing Malaria Intervention Control with A Cluster-Randomized SMART Trial

Environmental Modifications
in sub-Saharan Africa

Changing Epidemiology, Transmission and Pathogenesis of Plasmodium falciparum and P. vivax

Environmental Modifications
in sub-Saharan Africa

Changing Epidemiology, Transmission and Pathogenesis of Plasmodium falciparum and P. vivax

ICEMR • International Centers
of Excellence for Malaria Research

established a global network of independent research centers in malaria-endemic settings


Why Kenya & Ethiopia

Unlike other areas of the world, chronic hunger, food insecurity and famine
continue to affect millions of residents of sub-Saharan Africa

Primaquine Treatment

Ethiopia recently approved primaquine in the treatment regime, ideal for evaluating its effectiveness under field conditions

Mosquito insecticide resistance

Evolution of resistance. We will evaluate of new interventions (e.g., next generation nets, IVM)

Residual transmission

In low transmission settings can pose significant challenges to achieving malaria elimination goals

Impact of changing malaria transmission

The acquisition and maintenance of immunity and how this relates to susceptibility to symptomatic and severe malaria


Environmental Modifications in sub-Saharan Africa: Changing Epidemiology,
Transmission, and Pathogenesis of Plasmodium falciparum and P. vivax Malaria

To assess the impact of human environmental modifications such as dam construction, irrigation canals and shifting agricultural practices on the epidemiology, vector biology, transmission, pathogenesis and clinical manifestations of P. falciparum and P. vivax infection in the East African setting.
Understanding the consequences of expanding environmental modifications on local malaria ecosystems will allow for the rational development of novel and culturally appropriate surveillance and control/elimination strategies in a highly populated area of East Africa where high level insecticide resistance exists and public health interventions against malaria are limited primarily to insecticidal bed nets and indoor residual spraying of insecticides. Knowledge gained from this ICEMR is pertinent to malaria control in other under-studied regions of Africa where P. falciparum and P. vivax are co-endemic and drought, famine and/or human population movement and displacement are frequent.

Pop. at Risk: Ethiopia (Total Pop: 82M)


Pop. at Risk: Kenya (Total Pop: 53M)


ITN Coverage: Ethiopia


ITN Coverage: Kenya


P.vivax % in Ethiopia

Study Counties
Study Sties
Study Clusters
Field Staff
Total Household Enrolled
Total Resident-Visits
Mosquito Sampling Trap/Night
Larval Habitats Visits
IRS Sprayed Houses
PBO Net Distributed
LLIN Net Average Holes
Deployed Tablets

ICEMR Central Theme

To assess the impact of human environmental modifications on Plasmodium falciparum
and P. vivax infection in the East African setting

  • Epidemiology
  • Vector & Transmission
  • Pathogenesis & Immunity
  • Adaptive Interventions

Special Reseach

Special research projects related to Sub-Saharan Africa ICEMR

High-Altitude Migration

Wind-assisted, Long-distance, High-altitude Flight of Malaria Mosquitoes Research Question: Does high-altitude, long-distance flight occur in malaria vectors, and what is its role in malaria transmission maintenance?

Ultra-Sensitive PCR

Malaria Infection Diagnosis: The Value of Ultra-sensitive PCR Method Rationale: Asymptomatic individuals act as silent reservoirs of malaria transmission, perpetuating low-density transmission. Only the most mature gametocyte (stages iv – v) exist in peripheral blood circulation and offer a link in malaria transmission. .

Ultra-Sensitive RDT

Added Value of Ultra-sensitive RDT for Malaria Surveillance in the Context of Rapidly Changing Epidemiology? Aim: Evaluate whether recently developed ultrasensitive RDT (usRDT) provides a more sensitive and accurate diagnosis of Plasmodium falciparum in community and healthcare settings.

Hydro-Climatic Transmission Model

Water & Malaria: Hydrologic Model Development & Simulation Objective:Understand the location and duration of surface water detention being related to mosquito breeding; Investigate the impact of irrigation on the soil moisture and water storage in the field.

Urban Malaria

Urban Malaria and Invasive Vectors Malaria is traditionally associated with rural and tropical regions, but it is increasingly becoming a concern in urban settings, particularly in invasive vector areas.

Key Investigators

We are the malaria professionals

Regional Impacts

In the past decade, sub-Saharan African countries have experienced a new era of large dam constructions and expansion of irrigated agricultural farms to resolve famine and food shortage. These environmental changes may have unforeseen ecologic consequences that adversely affect human health. Knowledge gained from this ICEMR is important to malaria control, not only for the two study countries studied, but also to other regions of Africa prone to drought, famine, and large-scale human population movement.

ICEMR 2019 Annual Workshop

ICEMR Annual Workshop, July 23-27, 2019, in Nairobi, Kenya